Virginia Tech vs. Old Dominion odds, prediction: 2022 Week 1 college football picks by model on 45-32 run

Brent Pry will make his head coaching debut for the Virginia Tech Hokies when they take on the Old Dominion Monarchs in a non-conference matchup on Friday. Pry was an assistant for 30 seasons. The Hokies are coming off a 6-7 season, including a 4-4 Atlantic Coast Conference mark and third-place finish. The Monarchs, meanwhile, finished 2021 with a 6-7 overall record, including 5-3 in the Conference USA East Division. The Monarchs tied with Marshall for second place in the division. The Hokies lead the all-time series 2-1, with the home team winning all three meetings.

Kickoff from Kornblau Field at S.B. Ballard Stadium in Norfolk, Va., is set for 7 p.m. ET. The Hokies are 7-point favorites in the latest Virginia Tech vs. Old Dominion odds from Caesars Sportsbook, while the over/under for total points scored is set at 48. Before making any Virginia Tech vs. Old Dominion picks, be sure to check out the college football predictions and betting advice from the proven SportsLine Projection Model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Virginia Tech vs. Old Dominion and just locked in its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are the college football odds and betting lines for Virginia Tech vs. Old Dominion:

• Virginia Tech vs. Old Dominion spread: Virginia Tech -7 
• Virginia Tech vs. Old Dominion over/under: 48 points 
• Virginia Tech vs. Old Dominion money line: Virginia Tech -278, Old Dominion +222 
• VT: The under is 4-0 in the Hokies’ last four games in September 
• ODU: The Monarchs are 4-0 against the spread in their last four games against ACC foes 
• Virginia Tech vs. Old Dominion picks: See picks here.