College Football

Houston vs. UTSA odds, line, bets: 2022 college football picks, Week 1 predictions from proven computer model

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No. 24 Houston will begin a highly anticipated season when it faces UTSA in San Antonio on Saturday afternoon. The Cougars, who went 12-2 last year, are ranked inside the Top 25 to open the season for the first time since 2016. UTSA is coming off an outstanding season of its own, going undefeated in its first 11 games before winding up with a 12-2 record as well. 

Kickoff is set for 3:30 p.m. ET on CBS Sports Network. The Cougars are favored by four points in the latest UTSA vs. Houston odds from Caesars Sportsbook, while the over/under is set at 62. Before entering any Houston vs. UTSA picks, you’ll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,600 for $100 players on its top-rated college football picks against the spread. It enters Week 1 of the 2022 college football season on a 45-32 run on all top-rated college football side picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on UTSA vs. Houston. You can head to SportsLine to see its picks. Here are several college football odds for Houston vs. UTSA:

  • UTSA vs. Houston spread: Houston -4
  • UTSA vs. Houston over/under: 62 points

Featured Game | UTSA Roadrunners vs. Houston Cougars

Why Houston can cover

Houston is likely going to be one of the best offensive teams in college football again this season after ranking No. 11 in offensive touchdowns last season. The Cougars were picked to finish ahead of Cincinnati as the top team in the AAC, potentially putting them in line to make a run at a College Football Playoff spot. They have plenty of momentum entering the year after beating Auburn in the Birmingham Bowl, putting a bow on a 12-2 campaign. 

Senior quarterback Clayton Tune and junior wide receiver Nathaniel Dell are back to lead the offense after Dell accounted for 1,329 of Tune’s 3,546 passing yards last…

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