NFL Week 1 picks, plus Prisco’s power rankings and big records that could get broken in 2022

Welcome to the Tuesday edition of the Pick Six newsletter!

I’m not sure how it happened, but we are now just two days away from an actual professional football game being played. In just over 48 hours, the Rams and Bills will be opening the 2021 NFL season with a game in Los Angeles, but before that happens, we have about 300 more season predictions to get through, so we better get started.  

For today, we have the return of Pete Prisco’s Power Rankings, and in what might be the biggest surprise, he doesn’t have the defending Super Bowl champs ranked as his top team. Also coming today, I’ll be unveiling my picks for Week 1, and in what is not a surprise at all, I’m picking the Bengals to win. That’s what happens when you let a Bengals homer make NFL picks. Alright, let’s get to the rundown.  

Actually, before we get to the rundown, here’s a quick reminder to anyone who missed yesterday’s newsletter. For our Labor Day edition, we predicted the final record for all 32 teams and you can check that out by clicking here. Alright, now let’s really get to the rundown. 

As always, here’s your weekly reminder to tell all your friends to sign up for the Pick Six newsletter. To get your friends to sign up, all you have to do is click here and then share this link with them. 

1. Today’s show: Final preseason mailbag

During the NFL offseason, we like to spice things up each week on the Pick Six Podcast by adding a listener mailbag every Monday. As everyone knows, though, the mailman doesn’t deliver on Labor Day, so we couldn’t do a mailbag yesterday, which is why you’re getting our final Monday mailbag of the offseason on a Tuesday. 

Anyway, our mailbag episodes are pretty simple: We read listener questions during the show and then answer as many of those questions as possible. Questions can be about literally anything. I mean, I’m pretty sure someone once asked us if one-ply toilet paper is actually worse than two-ply. (The answer to that is definitely yes.) If we’ll answer that, trust me when I say that we’ll answer almost anything. 

Anyway, if you want to submit a question, all you have to do is go to Apple Podcasts (click here) and leave a five-star review that includes your question. 

Here’s one question that Ryan…