The Los Angeles Rams will try to win their sixth consecutive season-opener under coach Sean McVay when they host the Buffalo Bills on Thursday in the 2022 NFL Kickoff Game. The Rams will begin their Super Bowl 56 title defense against a Bills club that many observers have pegged as a Super Bowl participant this year, but recent history suggests Los Angeles comes prepared for the games that count. In fact, the Rams have won all five Week 1 encounters under McVay, including last year’s 34-14 blowout of the Chicago Bears.
Kickoff is at 8:20 p.m. ET. The Bills are 2.5-point favorites and the over-under for total points scored is 53 in the latest Bills vs. Rams odds from Caesars Sportsbook. Before locking any Rams vs. Bills picks, make sure you check out the NFL predictions and betting advice from SportsLine football analyst R.J. White.
White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine’s No. 1 expert in NFL picks against the spread. He went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. Moreover, he’s also 44-33 on NFL picks involving the Rams, lending critical insight into this matchup.
White is known for cashing out big in the Westgate Las Vegas SuperContest twice since 2015. He also cashed big on his NFL futures in 2021, including nailing Jonathan Taylor as the NFL rushing leader at 10-1. Anyone who has followed him has seen massive returns.
Now, White has studied the Bills vs. Rams Week 1 matchup from every angle and released a confident against-the-spread selection. You can head to SportsLine now to see White’s pick. Here are the NFL odds and betting lines for Bills vs. Rams:
- Bills vs. Rams point spread: Bills -2.5
- Bills vs. Rams over-under total: 53 points
- Bills vs. Rams money line: Bills -135, Rams +115
- BUF: Bills have covered four of the last five meetings in this rivalry
- LAR: Rams have covered five consecutive season-opening games
- Bills vs. Rams picks: See picks here
Featured Game | Los Angeles Rams vs. Buffalo Bills
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