The Buffalo Bills are the 2023 Super Bowl favorites, but the Los Angeles Rams will have something to say about that on Thursday in the 2022 NFL Kickoff Game. The Rams are the title-holders and host the NFL Week 1 showdown, but Buffalo enters the NFL Kickoff Game 2022 as the favorite. That’s because they are also favored to win Super Bowl LVII behind the Josh Allen-led offense and one of the NFL’s best defenses. The Rams have a high-powered offense of their own behind Matthew Stafford and receiver Cooper Kupp, who comes off a historic season. The Rams have won two Super Bowls (1999, 2021), while the Bills famously reached the big game four straight times (1990-93) but lost all four. They have yet to win one.
Kickoff in Inglewood, Calif. is set for 8:20 p.m. ET. Caesars Sportsbook lists Buffalo as a 2.5-point favorite in its latest Bills vs. Rams odds, with the over/under for total points scored set at 53. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine expert Mike Tierney.
A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Over the past four seasons, Mike is 232-204 ATS in his NFL picks. He is also 12-7-1 on his past 20 against-the-spread picks in Bills games, returning more than $400 to $100 bettors.
Now, Tierney has honed in on Bills vs. Rams in the NFL Kickoff Game 2022 and just revealed his NFL expert picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and betting trends for Rams vs. Bills:
- Bills vs. Rams spread: Buffalo -2.5
- Bills vs. Rams over/under: 53 points
- Bills vs. Rams money line: Buffalo -135, Los Angeles +115
- Bills: Defense allowed 4.6 yards per play in 2021, the only NFL team under 5.0
- Rams: QB Matthew Stafford averaged 8.1 yards per pass attempt, third-best in the NFL
- Bills vs. Rams picks: See picks at SportsLine
Featured Game | Los Angeles Rams vs. Buffalo Bills
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