As our guy Jim Nantz says: “Hello, friends!” The NFL is finally back in our lives with the regular-season opener and, boy, do we have a doozy of a matchup to begin the 2022 campaign. The defending Super Bowl champion Rams will unveil their banner and then begin their quest to repeat when they play host to the current betting favorite to win it all this year in the Buffalo Bills.
Here, we’ll specifically be looking at the different betting angles that this game has to offer. Along with the spread and total, we’ll also take a look at several player props and hand in our picks for how we see this prime-time matchup unfolding.
All NFL odds via Caesars Sportsbook.
How to watch
Date: Thursday, Sept. 8 | Time: 8:20 p.m. ET
Location: SoFi Stadium (Inglewood, California)
TV: NBC | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: Bills -2.5, O/U 52
Line movement
Latest Odds:
Los Angeles Rams
+2.5
This line initially had the Rams as a 1-point favorite when the schedule was released back in May. By the time our cookouts were done after the Fourth of July, this turned into a pick’em on July 6 and the pendulum started to swing in Buffalo’s favor. By the end of July and into early August, the Bills became the 1-point favorite and were soon bet up to -2.5 by Aug. 7 and that has held leading into Thursday’s head-to-head.
The pick: Rams -2.5. The defending champs are getting disrespected here. As good as the Bills are expected to be this season as the odds-on favorite to win the Super Bowl, the Rams are no slouch either. They have a defense that should be able to slow down this high-flying offense and while Matthew Stafford’s elbow injury is a bit of a concern long-term it shouldn’t be a factor in Week 1. It’s also worth mentioning that they have history on their side. Since Super Bowl XXIV, the defending champions are 13-6-2 ATS…
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