The Buffalo Bills are projected to be favored in every game they play during the 2022 NFL schedule. Perhaps the only one that caught football observers by surprise is that they are the betting favorite against the Super Bowl champion Los Angeles Rams on Thursday in the 2022 NFL Kickoff Game at SoFi Stadium. Buffalo is also the betting favorite at 6-1 to win this season’s Super Bowl and has taken four of the last five meetings with Los Angeles. The Rams have won five consecutive season-openers under coach Sean McVay and raised the Lombardi trophy the last time they played on their home turf. They defeated the Cincinnati Bengals 23-20 in Super Bowl 56 in February.
Kickoff in Inglewood, Calif. is set for 8:20 p.m. ET. Caesars Sportsbook lists Buffalo as a 2.5-point favorite in its latest Bills vs. Rams odds, with the over/under for total points scored set at 53. Before making any Rams vs. Bills picks, make sure to check out the expert NFL predictions and betting advice from SportsLine expert Mike Tierney.
A veteran sportswriter whose work appears periodically in the New York Times and Los Angeles Times, Mike Tierney has covered the NFL for decades and reported from seven Super Bowls. Over the past four seasons, Mike is 232-204 ATS in his NFL picks. He is also 12-7-1 on his past 20 against-the-spread picks in Bills games, returning more than $400 to $100 bettors.
Now, Tierney has honed in on Bills vs. Rams in the NFL Kickoff Game 2022 and just revealed his NFL expert picks and predictions. You can head to SportsLine now to see his picks. Here are several NFL odds and betting trends for Rams vs. Bills:
- Bills vs. Rams spread: Buffalo -2.5
- Bills vs. Rams over/under: 53 points
- Bills vs. Rams money line: Buffalo -135, Los Angeles +115
- Bills: Defense allowed 4.6 yards per play in 2021, the only NFL team under 5.0
- Rams: QB Matthew Stafford averaged 8.1 yards per pass attempt, third-best in the NFL
- Bills vs. Rams picks: See picks at SportsLine
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