UCF vs. Louisville odds, prediction, line, spread: 2022 Week 2 college football picks from model on 48-37 run

The UCF Knights have been making a habit of getting off to good starts, winning at least their first two games each of the last five campaigns. They began the run in 2017, when they won all 13 of their contests for the first undefeated season in school history. UCF attempts to continue the streak when it hosts the Louisville Cardinals on Friday. The Knights (1-0) opened the 2022 campaign with a convincing victory, a 56-10 triumph over South Carolina State. Louisville (0-1) was less than impressive in its opener, losing 31-7 at Syracuse.

Kickoff at FBC Mortgage Stadium in Orlando, Fla. is set for 7:30 p.m. ET. The Knights are 5.5-point favorites in the latest UCF vs. Louisville odds from Caesars Sportsbook, while the over/under for total points scored is 61.5. Before making any Louisville vs. UCF picks, you need to see the college football predictions and betting advice from the SportsLine Projection Model.

The model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,500 for $100 players on its top-rated college football picks against the spread. It enters Week 2 of the 2022 college football season on a 48-37 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on UCF vs. Louisville and just revealed its picks and CFB predictions. You can visit SportsLine now to see the model’s picks. Here are several college football odds and betting lines for Louisville vs. UCF: 

• UCF vs. Louisville spread: Knights -5.5 
• UCF vs. Louisville over/under: 61.5 points 
• UCF vs. Louisville money line: Knights -220, Cardinals +180
• UCF: The Knights are 1-6 against the spread in their last seven games following an ATS win 
• LOU: The Cardinals are 6-1 ATS in their last seven contests after scoring fewer than 20 points in their previous game 
• UCF vs. Louisville picks: See picks here.