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2022 NFL Week 1 picks against the spread: Baker Mayfield’s Panthers knock off Browns; Cowboys upset Tom Brady

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If Thursday night’s opener is any indication how Week 1 will go, home dogs are in a heap of trouble. Buffalo destroyed the Rams in front of the whole world, flexing some road chalk muscles to kick off the 2022 NFL season. I’m more inclined to expect a little more chaos than Thursday suggested, particularly when there’s so much unknown with a lot of different teams hitting the road as favorites. 

Having said that, I’m picking a Super Bowl matchup between a pair of Week 1 road favorites. My pick this year is Ravens over Eagles, the first ever bird matchup* we’ve seen in a Super Bowl (*according to John Breech, who almost certainly didn’t research it, so let’s not get too aggressive with any fact checking).

People are too low on Baltimore this year, getting a motivated Lamar Jackson and a much healthier roster. John Harbaugh will have this team fully back into the hunt for the No. 1 seed.

As for the Eagles, people are bizarrely against the idea Jalen Hurts can take a leap forward. He’s only 24 years old — it just feels like he’s closer to 30 because of how long he’s been in the general spotlight. Philly is deep on the offensive and defensive lines and upgraded big time at receiver with the A.J. Brown trade. 

The Bills look like justifiable favorites after the opening game, but it’s a long season ahead. 

All NFL odds are via Caesars Sportsbook

NFL Week 1 Picks

Ravens at Jets

Sunday, 1 p.m. ET
TV: 
CBS | Stream: Paramount+ (click here)

Latest Odds:

New York Jets
+6.5

Joe Flacco revenge game! Did not see this coming when we started prepping for the 2022 season. There’s a chance he’s an upgrade over Zach Wilson, at the very least for this initial Week 1 matchup against Flacco’s old team. Before 2021, Baltimore had a dominant Week 1 run. Even with the overtime loss to the Raiders last year, the Ravens have a +119 point differential in…

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