The San Francisco 49ers hit the road to take on the Chicago Bears in a NFL Week 1 matchup at 1 p.m. ET on Sunday at Soldier Field. The Niners are looking to build off a trip to the NFC Championship Game in 2021, but will be transitioning to Trey Lance as their new full-time starting quarterback. The Bears will be guided by first-year head coach Matt Eberflus and will be leaning on quarterback Justin Fields to take a big step in his second NFL season. San Francisco leads the all-time series 35-32-1.
San Francisco is favored by 7 points in the latest Bears vs. 49ers odds from Caesars Sportsbook, and the over/under is set at 41.5. Before making any 49ers vs. Bears picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Bears vs. 49ers and just locked in its picks and NFL Week 1 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Niners vs. Bears:
- Bears vs. 49ers spread: 49ers -7
- Bears vs. 49ers over/under: 42 points
- Bears vs. 49ers picks: See picks here
Featured Game | Chicago Bears vs. San Francisco 49ers
Why the Bears can cover
The Bears have high hopes for Fields, who flashed glimpses of having high-level NFL starter ability as a rookie in 2021. Wide receiver Darnell Mooney emerged as the Bears top target a year ago, and has Pro Bowl potential on the outside.
Roquan Smith ended his holdout and returned to the team in time for…
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