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Bears vs. 49ers prediction, odds, line, spread: 2022 NFL picks, Week 1 best bets from proven computer model

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The Chicago Bears host the San Francisco 49ers in a NFL Week 1 game between teams trending in different directions. The Bears, led by first-year head coach Matt Eberflus and second-year quarterback Justin Fields, are in rebuilding mode and looking to rejoin the elite teams of the NFC. The 49ers, led by head coach Kyle Shanahan, are looking to take the next step and build off their trip to the NFC Championship Game last year. Trey Lance will be making his first career Week 1 start for the Niners after filling in for Jimmy Garoppolo in three games as a rookie in 2021. The Bears lead the all time series 35-32-1.

San Francisco is favored by 6.5 points in the latest 49ers vs. Bears odds from Caesars Sportsbook, and the over/under is set at 40. Before making any Bears vs. 49ers picks, you need to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 138-97 run on top-rated NFL picks that dates back to the 2017 season. Amazingly, it hasn’t missed a top-rated pick since Week 15 last season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94 percent of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bears vs. 49ers and just locked in its picks and NFL Week 1 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for 49ers vs. Bears:

  • Bears vs. 49ers spread: 49ers -6.5
  • Bears vs. 49ers over/under: 40 points
  • Bears vs. 49ers picks: See picks here

Featured Game | Chicago Bears vs. San Francisco 49ers

Why the Bears can cover

The Bears have high hopes for Fields, who flashed glimpses of having high-level NFL starter ability as a rookie in 2021. Wide receiver Darnell Mooney emerged as the Bears top target a year ago, and has Pro Bowl potential on the outside. 

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