Playing the New Orleans Saints has been a House of Horrors for Tom Brady throughout his career. Brady has a 4-5 regular season record versus New Orleans, making it just one of two teams he is under .500 against (Seattle, 1-2). Even with that, Brady and his Buccaneers are three-point favorites versus Jameis Winston, Alvin Kamara and New Orleans in the latest NFL odds at Caesars Sportsbook. Just four other games have Week 2 NFL spreads of three points or fewer.
One of those is Brady’s former team, the New England Patriots, who are one-point favorites versus Pittsburgh in the NFL Vegas odds. Patriots vs. Steelers on Sunday will look a little different too, as it will be the first game between the teams since 1998 in which neither Brady nor Ben Roethlisberger is on the field. Both Mac Jones (back) and T.J. Watt (chest) suffered opening-game injuries, so how will those sway your Week 2 NFL bets? All of the Week 2 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 2 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up over $7,500 for $100 players on top-rated NFL picks since its inception. The model enters the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 2 NFL odds from Caesars and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 2 NFL predictions
One of the model’s strongest Week 2 NFL picks is that the Browns (-6.5) cover at home against the Jets. Cleveland spoiled Baker Mayfield’s revenge party with a road victory over Carolina in Week 1 in which it dominated in the trenches on offense and defense. The Browns ran for 217 yards, as Nick Chubb and Kareem Hunt combined for over 200 scrimmage yards and two touchdowns. Cleveland’s defensive line took control of the game from there and sacked Mayfield four times. The former Browns quarterback also fumbled four times.
Meanwhile, New York is coming off a 24-9 defeat to the Ravens in which it showed that not much has changed from last year. In 2021, the…
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