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49ers vs. Seahawks prediction, odds, line, spread: 2022 NFL picks, Week 2 best bets from proven computer model

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NFC West rivals are set to battle with the Seattle Seahawks and the San Francisco 49ers set to face off at 4:05 p.m. ET on Sunday at Levi’s Stadium in Santa Clara. The Niners are looking to bounce back from a disappointing 19-10 Week 1 loss to the Chicago Bears, with the Seahawks are looking to build off their surprising 17-16 win over the Denver Broncos on the Monday Night Football season opener. The Seahawks lead the all-time series 30-17 and have won five of the last six meetings in this rivalry. 

San Francisco is favored by 10 points in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, and the over/under is set at 42.5. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Seahawks and just locked in its Week 2 NFL picks and predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for 49ers vs. Seahawks:

  • 49ers vs. Seahawks spread: 49ers -10
  • 49ers vs. Seahawks over/under: 42 points
  • 49ers vs. Seahawks picks: See picks here

Featured Game | San Francisco 49ers vs. Seattle Seahawks

What you need to know about the 49ers

The 49ers came up short against the Chicago Bears this past Sunday, falling 19-10 in ugly conditions. Quarterback Trey Lance turned in an up-and-down performance in Week 1 throwing for 164 yards and an interception while completing less than 50% of his passes in a steady rain storm. He was also the team’s leading…

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