Week 1 of the 2022 NFL season was a thriller that featured some wild upsets. The Chicago Bears took down the San Francisco 49ers, the New York Giants pulled off an incredible comeback against the Tennessee Titans, and Russell Wilson lost in his return to Seattle. Expect more madness in Week 2.
Thankfully, the experts at CBS Sports and SportsLine have you covered to guide you through this weekend’s slate. Each week, we’ll collect all of the best picks and gambling content from CBSSports.com and SportsLine in one place, so you can get picks against the spread from our CBS Sports experts as well as additional feature content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more.
All NFL odds via Caesars Sportsbook.
Which picks can you make with confidence in Week 2? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up more than $7,500 for $100 players on top-rated NFL picks since its inception.
Tampa Bay Buccaneers at New Orleans Saints
Time: Sunday, 1 p.m. ET (Fox), stream on fuboTV (try for free)
Open: Buccaneers -4, O/U 46.5
Featured Game | New Orleans Saints vs. Tampa Bay Buccaneers
“I have no idea why Tom Brady took 11 days off in the middle of training camp this year, but to me, the most likely theory is that he did it so he could study the Saints defense for 264 straight hours without being interrupted. If there’s one team Brady has not been able to figure out since signing in Tampa Bay, it’s definitely the Saints.
“Brady has played the Saints four times in the regular season over the past two years, and not only has he gone 0-4 in those games, but the Buccaneers have lost all four games by multiple scores. In their second meeting of the 2021 season, the Buccaneers lost, 9-0, which is mostly notable because it marks the only time over the past 15 years that Brady has been shut out.
“When Brady announced…