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2022 NFL Week 2 Picks Against Spread: Patriots bounce back vs Steelers, Packers roll Bears

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NFL Week 2 is almost always an impossible endeavor because we have to take priors we had coming into the season, watch them go up in flames during Week 1 and also try not to overreact to what we saw in the first week when making selections for the second stanza of the season. 

There was chaos everywhere last week, with a multitude of significant favorites losing (and singlehandedly wiping out survivor leagues). 

Now several of those teams are favored, and there are a few poorly performing teams who are double-digit favorites. The schedule- makers did us no favors with these second-week matchups because the point spreads are so inflated for teams who we can’t quite trust. 

Let’s try and navigate the chaos. 

All NFL odds are via Caesars Sportsbook

NFL Week 2 Picks

Chargers at Chiefs

Thursday, 8:20 p.m. ET
Amazon Prime 
Follow: CBS Sports App

Featured Game | Kansas City Chiefs vs. Los Angeles Chargers

It’s the first Thursday night game on Amazon Prime. Prepare yourself, because someone in your family (aunt, uncle, mom, dad, someone) will text you asking where the hell this game is being played. Kindly explain to them: All the packages arriving at their house with free shipping entitles them to watch this game via a basic streaming service. The Chiefs looked AWESOME in Week 1 and the Chargers were quite nice as well. This is the fourth meeting between Patrick Mahomes and Justin Herbert (Week 17 of 2020 Mahomes didn’t start because the division was clinched) and all three previous meetings have been decided by a game-winning score either in the final minute of regulation or overtime. If you want to bet the total, take it live when one team is down two scores and has to start winging it around. I’m backing Mahomes here. 

The pick: Chiefs 28, Chargers 21

Props, Best Bets: Chiefs -4

Colts at Jaguars

Sunday, 1 p.m. ET
CBS | Stream: Paramount+ (click here)

Featured Game | Jacksonville Jaguars vs. Indianapolis Colts

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