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Bills vs. Titans odds, spread, line: Monday Night Football picks, predictions from NFL model on 139-98 run

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The Tennessee Titans (0-1) will visit the Buffalo Bills (1-0) in the first half of a Monday Night Football doubleheader to round out the Week 2 NFL schedule. This primetime matchup features Buffalo quarterback Josh Allen, receiver Stefon Diggs, and safety Micah Hyde. On the opposite side, Tennessee has running back Derrick Henry, quarterback Ryan Tannehill, and safety Kevin Byard. The Bills are one of the top 2023 Super Bowl favorites, while the Titans were the top seed in the AFC playoff picture last season.

Kickoff from Highmark Stadium in Orchard Park, N.Y., is set for 7:15 p.m. ET. Buffalo is favored by 10 points in the latest Bills vs. Titans odds from Caesars Sportsbook, and the over/under is 47.5. Before making any Titans vs. Bills picks, you need to see the NFL predictions and betting advice from SportsLine’s advanced computer simulation model.

The model, which simulates every NFL game 10,000 times, is up more than $7,500 for $100 players on top-rated NFL picks since its inception. The model enters Week 2 of the 2022 NFL season on an incredible 139-98 run on top-rated NFL picks that dates back to the 2017 season. 

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Titans and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Now, here are several NFL odds and betting lines for Titans vs. Bills:

  • Bills vs. Titans spread: Buffalo -10
  • Bills vs. Titans over/under: 47.5 points
  • Bills vs. Titans money line: Tennessee +360, Buffalo -480
  • TEN: Titans are 8-2 ATS in their last 10 Monday games
  • BUF: Bills are 3-0-1 ATS in their last four home games
  • Bills vs. Titans picks: See picks here

Featured Game | Buffalo Bills vs. Tennessee Titans

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