College Football

Baylor vs. Iowa State odds, line: 2022 college football picks, Week 4 predictions from proven computer model

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The No. 17 Baylor Bears will open the Big 12 portion of the season when they face the Iowa State Cyclones on Saturday afternoon. Baylor lost to No. 21 BYU in double overtime two weeks ago, but it bounced back with a 42-7 win over Texas State last week. Iowa State has won its first three games of the season, including a 43-10 win over Ohio its last time out. 

Kickoff is set for noon ET. The Cyclones are favored by 2.5 points in the latest Iowa State vs. Baylor odds from Caesars Sportsbook, while the over/under is set at 45.5. Before entering any Baylor vs. Iowa State picks, you’ll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Iowa State vs. Baylor. You can head to SportsLine to see its picks. Here are several college football odds for Iowa State vs. Baylor:

  • Iowa State vs. Baylor spread: Iowa State -2.5
  • Iowa State vs. Baylor over/under: 46 points
  • Iowa State vs. Baylor picks: See picks here

Featured Game | Iowa State Cyclones vs. Baylor Bears

Why Iowa State can cover

Iowa State has put together three solid performances already this season, including a 10-7 road win at Iowa in Week 2. The Cyclones have also recorded blowout wins over Southeast Missouri State and Ohio at home, giving them plenty of confidence heading into this game. Sophomore quarterback Hunter Dekkers has completed 74.3% of his passes for 745 yards and eight touchdowns, with senior wide receiver Xavier Hutchinson catching 28 of those throws for 319 yards and five scores. 

Junior running back Jirehl Brock is off to a good start as well,…

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