Clemson vs. Wake Forest odds, prediction, line: 2022 Week 4 college football picks by model on 51-43 run

The No. 5 Clemson Tigers look to continue their winning ways when they take on the No. 21 Wake Forest Demon Deacons in an ACC Atlantic Division matchup on Saturday. The Tigers (3-0) enter the game having won nine in a row, which is the nation’s longest active winning streak. The Demon Deacons (3-0) are looking to build off last year’s success, which saw them win the division with a 7-1 mark and finish 11-3 overall. Clemson was second in the division at 6-2 and was 10-3 overall.

Kickoff from Truist Field in Winston-Salem, N.C., is set for noon ET. Clemson leads the all-time series 69-17-1, including a 26-10-1 record at Wake Forest. The Tigers are 7-point favorites in the latest Clemson vs. Wake Forest odds from Caesars Sportsbook, while the over/under for total points scored is set at 55.5. Before making any Wake Forest vs. Clemson picks, you need to see the college football predictions and betting advice from SportsLine’s advanced computer simulation model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Wake Forest and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Wake Forest vs. Clemson:

• Clemson vs. Wake Forest spread: Clemson -7
• Clemson vs. Wake Forest over/under: 55.5 points
• Clemson vs. Wake Forest money line: Clemson -285, Wake Forest +228
• CLEM: The Tigers are 4-0 against the spread in their last four conference games
• WF: The Demon Deacons are 4-1 ATS in their last five games in September
• Clemson vs. Wake Forest picks: See picks at SportsLine