College Football

South Carolina vs. Charlotte prediction, odds, line: College football picks, Week 4 best bets by proven model

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The South Carolina Gamecocks will take on the Charlotte 49ers at 7:30 p.m. ET on Saturday at Williams-Brice Stadium. The Gamecocks are 1-2 overall and 1-1 at home, while Charlotte is 1-3 overall and 1-1 on the road. This will be the first matchup between USC and the 49ers football program, which began FBS play in 2015. 

The Gamecocks are favored by 22 points in the latest South Carolina vs. Charlotte odds from Caesars Sportsbook, and the over/under is set at 69. Before making any South Carolina vs. Charlotte picks, you’ll want to see the college football predictions from the model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of more than $3,300 for $100 players on its top-rated college football picks against the spread. It enters Week 4 of the 2022 college football season on a 51-43 run on all top-rated college football spread and money-line picks that dates back to 2021. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Charlotte and just locked in its picks and CFB predictions. You can head to SportsLine to see its picks. Here are several college football odds and betting lines for South Carolina vs. Charlotte:

  • South Carolina vs. Charlotte spread: South Carolina -22
  • South Carolina vs. Charlotte over/under: 69 points
  • South Carolina vs. Charlotte picks: See picks here

Featured Game | South Carolina Gamecocks vs. Charlotte 49ers

What you need to know about South Carolina

The day started off rough for the Gamecocks on Saturday, and it ended that way too as they were pulverized by the Georgia Bulldogs 48-7. USC was in a tough position by the half, with the score already sitting at 24-0. QB Spencer Rattler had a memorable game, but not in the way you want to be remembered as besides failing to produce a single touchdown, he threw two interceptions with only 4.72 yards per passing attempt.

A transfer from Oklahoma, Rattler was a Heisman…

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