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Panthers vs. Cardinals prediction, odds, line, spread: 2022 NFL picks, Week 4 best bets from proven model

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Baker Mayfield and the Carolina Panthers (1-2) will take on Kyler Murray the Arizona Cardinals (1-2) on Sunday at Bank of America Stadium in Charlotte. The Panthers are coming off an impressive 22-14 win over the New Orleans Saints in Week 3, while the Cardinals are hoping to bounce back from a 20-12 loss to the defending Super Bowl champion Los Angeles Rams. The Panthers and Cardinals have met 19 times with Carolina holding a 14-5 advantage. Carolina All-Pro running back Christian McCaffrey (thigh) remains questionable for this matchup.

Kickoff is at 4:05 p.m. ET. Carolina is a 1-point favorite in the latest Panthers vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 43.5. Before making any Cardinals vs. Panthers picks, you’ll want to see the NFL predictions and betting advice from the computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 4 of the 2022 NFL season on an incredible 139-103 run on top-rated NFL picks that dates back to the 2017 season. The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Panthers vs. Cardinals and just locked in its picks and NFL Week 4 predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Cardinals vs. Panthers:

  • Panthers vs. Cardinals spread: Panthers -1
  • Panthers vs. Cardinals over/under: 43.5 points
  • Panthers vs. Cardinals picks: See picks here

Featured Game | Carolina Panthers vs. Arizona Cardinals

What you need to know about the Panthers

The Panthers beat the New Orleans Saints 22-14 this past Sunday. Carolina’s WR Laviska Shenault Jr. filled up the stat sheet, catching two passes for one TD and 90 yards. Near the top of the highlight reel was Baker Mayfield’s 67-yard…

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