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NFL DFS Monday Night Football picks: Optimal Rams vs. 49ers fantasy lineup advice for DraftKings, FanDuel

NFL DFS Monday Night Football picks: Optimal Rams vs. 49ers fantasy lineup advice for DraftKings, FanDuel


Week 4 of the 2022 NFL schedule comes to a close with a NFC West rivalry game between the Los Angeles Rams and San Francisco 49ers on Monday NIght Football. The 49ers, led by Jimmy Garoppolo, are coming off a hard-fought 11-10 loss to the Denver Broncos, while Matthew Stafford, Aaron Donald and the Rams are coming off back-to-back wins after defeating the Arizona Cardinals in Week 3. Los Angeles wide receiver Cooper Kupp, who is coming off a 2021 season where he led the NFL in receptions, yards, and touchdowns, could be a must-start option in your NFL DFS lineups and NFL DFS stacks. Alternately, it could make sense to build your MNF Showdown NFL DFS strategy around another star wide receiver, quarterback, running back, tight end, or defense. George Kittle, Deebo Samuel, Jeff Wilson Jr., Cam Akers, and Allen Robinson all project to be impact classic and showdown NFL DFS picks for Monday Night Football. 

Before making any NFL DFS picks of your own for 49ers vs. Rams on sites like DraftKings and FanDuel, be sure to check out the NFL DFS lineup advice, strategy and player stacks from SportsLine NFL daily Fantasy expert Jimmie Kaylor

Kaylor is a NFL and DFS expert for SportsLine, who opened the 2022 NFL season by winning DraftKings’ NFL Showdown Thursday Kickoff Millionaire contest. He edged out over 355,000 other entrants in the contest and also has multiple five-figure tournament wins on his DFS resume. Kaylor has covered the NFL and college football for close to a decade as a member of the Pro Football Writers of America, and his background as a former college and NFL player gives him a unique perspective when building his fantasy lineups and locking in his betting picks.

In Week 1 Monday Night Football, Kaylor listed Denver wide receiver Jerry Jeudy as one of his top Showdown DFS picks and the former Alabama star was the highest scoring fantasy player in the game. In Week 2 MNF, Kaylor called for a huge night from Buffalo wide receiver Stefon Diggs and he delivered 12 receptions for 148 yards and three touchdowns. In Week 3 TNF, Kaylor dominated with the Cleveland duo of Amari Cooper and Nick Chubb. Last week, he was all over Dallas wide receiver CeeDee Lamb, who was the highest scorer in the game.

Now, Kaylor has turned his attention to Rams vs. 49ers on Monday Night Football Week 4 and just locked in his top daily Fantasy football picks. You can only see his picks and analysis at…

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