A Thursday Night Football matchup features the Denver Broncos (2-2) hosting the Indianapolis Colts (1-2-1) in a primetime battle. The Colts will be without star running back Jonathan Taylor, who is out with an ankle injury, while the Broncos will be without young running back Javonte Williams, who is out for the season with a torn ACL. Last Sunday, the Colts lost to the Tennessee Titans, 24-17. Similarly, Denver fell to the Las Vegas Raiders, 32-23.
Kickoff is set for 8:15 p.m. ET in Denver. Caesars Sportsbook lists Denver as a three-point favorite in the latest Broncos vs. Colts odds. The over/under for total points is 42. Before making any Colts vs. Broncos picks, be sure to check out the NFL predictions and betting advice from the SportsLine Projection Model.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 5 of the 2022 NFL season on an incredible 140-105 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on Broncos vs. Colts and just locked in its picks and TNF predictions. You can visit SportsLine now to see the model’s picks. Here are the NFL odds and betting lines for Colts vs. Broncos:
- Broncos vs. Colts spread: Denver -3
- Broncos vs. Colts over/under: 42 points
- Broncos vs. Colts money line: Indianapolis +143, Denver -170
- IND: Colts are 5-1 against the spread in their last six games following a straight-up loss
- DEN: Broncos are 5-0 ATS in their last five home games against teams with losing road records
- Broncos vs. Colts picks: See picks here
Featured Game | Denver Broncos vs. Indianapolis Colts
Why the Broncos can cover
Denver’s defensive line has players who can create pressure and get after the quarterback. Defensive end Dre’Mont Jones is underrated and consistently makes plays. Jones is solid against the run with pass-rush…
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