For all the struggles that the Jacksonville Jaguars had against the Houston Texans last Sunday, they could have positioned themselves for a game-winning drive with just over seven minutes to play. However, an unsportsmanlike conduct penalty gave the Texans (+7) new life on their drive, which ended in a Dameon Pierce touchdown run and Houston’s ninth consecutive win against Jacksonville. In a wide-open AFC South, the Jags are quickly losing ground and are two-point underdogs at Indianapolis in the latest Week 6 NFL odds on Caesars Sportsbook, one of the slimmest NFL spreads of the week.
The Colts are just 2-3 against the spread this season, but could be among the Week 6 NFL best bets in a revenge spot on Sunday after getting shut out by the Jags in Week 2 on the road. All of the Week 6 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 6 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up almost $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 6 of the 2022 NFL season on an incredible 146-106 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 6 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 6 NFL predictions
One of the model’s strongest Week 6 NFL picks is that the Giants (+6) cover the spread at home against the Ravens. New York is one of the most surprising teams this season with 4-1 records overall and against the spread. In the first half of games this season, the Giants have the eighth-highest rush success rate (46.9 percent) thanks to the resurgence of star running back Saquon Barkley.
Barkley is already just 60 yards shy of his total rushing yardage output from last season (593 yards). He finished last year with just two rushing touchdowns, but already has three through his first five games. The Ravens have only allowed 540 total rushing yards this season, but do so at a clip of five yards per attempt by opponents. The model predicts that Barkley will finish with 87 rushing…
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