The Pittsburgh Panthers and the Louisville Cardinals will face off in an ACC clash on Saturday night at Cardinal Stadium in Louisville, KY. The Panthers are 4-2 overall and enter off a bye week following a 45-29 win over Virginia Tech. Louisville is 3-3 and hammered Virginia 34-17 before their bye week in Week 7. The teams last played in 2020, when Pittsburgh got the home win, 23-20. The Cardinals are 3-3 against the spread, while the Panthers are 2-3 ATS in 2022.
Kickoff is scheduled for 8:00 p.m. ET. The Cardinals are favored by 2.5 points in the latest Louisville vs. Pittsburgh odds from Caesars Sportsbook, and the over/under is set at 55. Before entering any Pittsburgh vs. Louisville picks, you’ll want to see the college football predictions and betting advice from the model at SportsLine.
The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.
Now, the model has set its sights on Louisville vs. Pittsburgh and just locked in its picks and CFB predictions. You can head to SportsLine to see its picks. Here are several college football odds and betting lines for Louisville vs. Pittsburgh:
- Louisville vs. Pittsburgh spread: Louisville -2.5
- Louisville vs. Pittsburgh over/under: 55 points
- Louisville vs. Pittsburgh picks: See picks here
Latest Odds:
Louisville Cardinals
-2.5
What you need to know about Louisville
The Cardinals will be happy to welcome back star quarterback Malik Cunningham after he missed the Virginia game two weeks ago due to injury. In his absence though, backup QB Brock Domann threw for 275 yards and a touchdown in addition to rushing for 71 yards on nine attempts and another score….
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