Deebo Samuel OUT vs. Rams

DL Arik Armstead (foot, ankle)
LB Dre Greenlaw (calf)
FB Kyle Juszczyk (finger)
WR Deebo Samuel (hamstring)

Replacing these four players won’t be easy for the 49ers. Armstead’s absence has been apparent since he was hurt in Week 4 against the Rams. Greenlaw’s replacement, Demetrius Flannigan-Fowles, struggled badly against the Chiefs. Juszczyk is the only fullback on the roster and third tight end Ross Dwelley will likely be his replacement. Samuel is the most unique offensive player in the league, and San Francisco doesn’t have another receiver with his skill set. Overcoming this quartet’s absence is the biggest key for the 49ers on Sunday.