The Buffalo Bills will attempt to bounce back from a stunning loss, and may have to do it without their star quarterback, when they host the red-hot Minnesota Vikings on Sunday during the Week 10 NFL schedule. AFC East-leading Buffalo was off to a 6-1 start and had won four in a row before suffering a 20-17 setback at the division-rival New York Jets last week. Josh Allen suffered an elbow injury late in the defeat. The Bills are 5.5-point favorites against the Vikings, who have won six straight, in the latest Week 10 NFL odds at Caesars Sportsbook. Which Week 10 NFL lines should you target with your Week 10 NFL bets? Before you make any Week 10 NFL picks or NFL parlays, be sure to see the NFL predictions and betting advice from SportsLine’s proven computer model.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has locked in five confident NFL best bets for Week 10. If you successfully parlay its picks, you’d be looking at a massive payout of around 25-1. You can only see the model’s Week 10 NFL picks at SportsLine.
Top Week 10 NFL picks
After simulating every game 10,000 times, the model is high on the Tennessee Titans (-3) to cover the spread against the Denver Broncos. The Titans will be eager to atone for last week as they squandered a fourth-quarter lead and suffered a 20-17 overtime loss at Kansas City, ending their five-game winning streak. Tennessee hopes to have quarterback Ryan Tannehill (ankle) back after a two-game absence, but will be led by two-time NFL rushing leader Derrick Henry, who overtook Cleveland’s Nick Chubb for the lead this season with his fifth straight 100-yard performance last week.
Henry, who has gained 870 yards on the ground, will face a Denver defense that is in the bottom-third in the league against the run with an average of 122.6 yards allowed. The Broncos are producing 15.1 points per game, which ranks 30th, and eclipsed the 20-point mark last week for just the…
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