Football fans have been waiting for a Joe Mixon breakout game for the past few seasons, but Cincinnati’s commitment to getting him going in the run game has been inconsistent. Mixon took matters into his own hands in Week 9 and ran for 153 yards and four touchdowns against the Carolina Panthers, with 58 receiving yards and another score in a 42-21 win. Mixon and the Bengals are on bye this week, but big-time running backs who were off last week are back in action on Sunday. Nick Chubb and the Browns are 3.5-point underdogs to the Miami Dolphins in the Week 10 NFL odds at Caesars Sportsbook, while Saquon Barkley and the Giants are 4.5-point home favorites against Houston in the NFL spreads. Which teams should you target in your NFL survivor picks and NFL office pool picks? All of the Week 10 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 10 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 10 of the 2022 NFL season on an incredible 151-108 run on top-rated NFL picks that dates back to the 2017 season.
The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 10 NFL odds and locked in picks for every NFL matchup. Head here to see every pick.
Top Week 10 NFL predictions
One of the model’s strongest Week 10 NFL picks is that the Titans (-2.5) cover the spread at home against the Broncos almost 60% of the time. The Broncos had a bye week following their narrow win in London against the Jacksonville Jaguars in Week 8, but have been underwhelming this season. Prior to Week 8, Denver had lost four consecutive games.
Meanwhile, Tennessee is coming off of an overtime loss to Kansas City in Week 9, but has been without quarterback Ryan Tannehill for the last two games. Fortunately for the Titans, they haven’t needed much from the passing game with running back Derrick Henry playing so well. Since Week 4, he has rushed for 678 yards with seven touchdowns, while the Broncos have allowed 346 total rushing yards over their last two games.
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