College Football

Clemson vs. Louisville odds, line, spread: 2022 college football picks, Week 11 predictions from proven model

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The Clemson Tigers will try to bounce back from their first loss of the season when they face the Louisville Cardinals on Saturday afternoon. Clemson won its first eight games prior to losing at Notre Dame last week. Meanwhile, Louisville is riding a four-game winning streak following its 34-10 win against James Madison

Kickoff is set for 3:30 p.m. ET. The Tigers are favored by 7 points in the latest Clemson vs. Louisville odds from Caesars Sportsbook, while the over/under is set at 52. Before entering any Louisville vs. Clemson picks, you’ll want to see the college football predictions from the proven computer model at SportsLine.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Clemson vs. Louisville. You can head to SportsLine to see its picks. Here are several college football odds for Clemson vs. Louisville:

  • Clemson vs. Louisville spread: Clemson -7
  • Clemson vs. Louisville over/under: 52 points
  • Clemson vs. Louisville money line: Clemson -278, Louisville +222
  • Clemson vs. Louisville picks: See picks here

Featured Game | Clemson Tigers vs. Louisville Cardinals

Why Clemson can cover

Clemson is coming off a road loss to Notre Dame, but it has still picked up wins over three ranked opponents this season. The Tigers cannot afford another loss if they want to remain in contention for a spot in the College Football Playoff, so they will be motivated for this game. They are riding a 38-game home winning streak and have never lost to Louisville in seven previous meetings. 

The Tigers have gone 14-0 in their last 14 games following a loss and still have one of the best defenses in the country. Junior quarterback DJ Uiagalelei has thrown for nearly 2,000 yards and 18 touchdowns this season, while also rushing for 373 yards and four scores….

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