Key matchups to watch in Week 10

Tennessee’s elite run defense will take a hit this week without Jeffery Simmons, but the group upfront still has enough to limit the damage, especially with the Broncos not being very good at running the ball.

The bigger concern is Tennessee’s pass-rush, which will be without both Simmons and Bud Dupree, the two biggest difference-makers in that area.

Dupree’s early exit was no doubt a blow to the pass-rush last week, but the Titans also struggled to contain Patrick Mahomes afterwards, and that issue could rear its ugly head again in Week 10 thanks to Russell Wilson’s ability to make plays with his legs.

Rashad Weaver, who has been quiet and hasn’t tallied a sack in his last three games, must step up and get to the quarterback, while also securing the edge and making sure Wilson doesn’t escape when Tennessee does get pressure.

Adding to that concern, the secondary will be short-handed, with Amani Hooker already ruled out. Kristian Fulton is on the fence ahead of Sunday, and his absence would be an even bigger blow to Tennessee’s coverage.

Granted, the Broncos haven’t exactly been lighting the world on fire and their offensive line is exploitable, but it’s going to be much tougher to take advantage of that weakness with all the injuries.

Also, they do still have Russell Wilson under center and a trio of talented pass-catchers in tight end Greg Dulcich and receivers Jerry Jeudy and Courtland Sutton.

If the pass-rush doesn’t bother Wilson enough, Tennessee’s banged-up secondary is going to have a hell of a time trying to cover that trio for an extended period of time.