West Coast teams hoping to improve their positioning in the 2022 NFL playoff picture will collide when the San Francisco 49ers host the Los Angeles Chargers in the Week 10 Sunday Night Football game at Levi’s Stadium. The Niners (4-4), who reached the NFC Championship Game last year, sit in second place in the NFC West, 1 ½ games behind the surprising Seahawks (6-3). San Francisco is coming off a bye week in Week 9. Meanwhile, the Chargers (5-3) are in second place in the AFC West standings, one game behind the Chiefs (6-2). Last week, Los Angeles escaped Atlanta with a 20-17 victory.
Kickoff is set for 8:20 p.m. ET. San Francisco is a 7.5-point favorite in the latest Chargers vs. 49ers odds from Caesars Sportsbook, while the over/under for total points scored is 45. Before making any 49ers vs. Chargers picks or Week 10 NFL predictions, you need to see what SportsLine’s resident Chargers expert, R.J. White, has to say.
White, a Fantasy and gambling editor for CBS Sports, consistently crushes as SportsLine’s No. 1 expert in NFL picks against the spread and went 445-378-24 on his ATS picks from 2017-21, which returned $2,542 to $100 players. He’s also gone a whopping 19-7-1 on his last 27 against-the-spread picks involving the Chargers, meaning he’s well-qualified for this selection.
Now, he has locked in on 49ers vs. Chargers and released his confident SNF picks. Go to SportsLine to see them. Here are the NFL lines and trends for Chargers vs. Niners:
- Chargers vs. 49ers spread: San Francisco -7.5
- Chargers vs. 49ers over/under: 45 points
- Chargers vs. 49ers money line: San Francisco -350, Los Angeles +275
- SF: 49ers lead the league in total defense (285.9 yards per game)
- LAC: RB Austin Ekeler leads the NFL in touchdowns (10)
- Chargers vs. 49ers picks: See picks at SportsLine
Featured Game | San Francisco 49ers vs. Los Angeles Chargers
Why the 49ers can cover
San Francisco’s running attack has a favorable matchup going up against the Los Angeles defense. The Chargers have given up 5.7 yards per carry this season, which is…
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