This week, the NFL heads to Mexico City, Mexico, where the San Francisco 49ers (5-4) will face the Arizona Cardinals (4-6) at Estadio Azteca on Monday, November 21, 2022. The 49ers are favored by 8 points. The over/under in the contest is set at 43.5 points.
In their last game, the 49ers won versus the Los Angeles Chargers, 22-16.
Against the Chargers, Jimmy Garoppolo completed 19 of 28 passes for 240 yards, with no touchdowns and no interceptions, for the Niners.
The Cardinals’ most recent game was against the Los Angeles Rams, and they won by a score of 27-17.
We dig deep into all of the details you need to know about this contest below, including how to watch on TV.
49ers vs Cardinals Betting Information
NFL odds courtesy of Tipico Sportsbook. Odds updated Friday at 8:47 PM ET. For a full list of sports betting odds, access USA TODAY Sports Betting Scores Odds Hub.
- Spread Favorite: San Francisco (-8)
- Moneyline: San Francisco (-364), Arizona (+290)
- Total: 43.5 points
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49ers Betting Info
- San Francisco has two wins against the spread and is 2-3 overall, away from home.
- The 49ers have covered the spread in a matchup four times this season (4-5-0).
- The 49ers are a perfect 1-0 ATS when playing as at least 8-point favorites.
- San Francisco has hit the over twice in five road games this year.
- This season, 49ers games have hit the over three times.
49ers Leaders
- Garoppolo: 1,931 PASS YDS / 241.4 YPG / 66.8% / 11 TD / 4 INT
- Christian McCaffrey: 125 CAR / 563 YDS / 62.6 YPG / 4 TD / 47 REC / 395 YDS / 43.9 YPG / 2 TD
- Deebo Samuel: 28 CAR / 165 YDS / 20.6 YPG / 1 TD / 34 REC / 411 YDS / 51.4 YPG / 2 TD
- Brandon Aiyuk: 44 REC / 567 YDS / 63.0 YPG / 4 TD
Place your legal, online sports bets in CO and NJ at Tipico Sportsbook now.
49ers vs Cardinals Game Info
- Game Day: Monday, November 21, 2022
- Game Time: 8:15 PM ET
- Location: Mexico City, Mexico
- Stadium: Estadio Azteca
- TV Channel: ESPN
- Live Stream: fuboTV (Watch for free)
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