The NFL returns to Mexico this week, as the San Francisco 49ers and Arizona Cardinals pay a visit to Estadio Azteca for a Monday night NFC West showdown. Both teams are coming off of wins, as the 49ers downed Justin Herbert and the Los Angeles Chargers last Sunday night, while Colt McCoy took down the Los Angeles Rams. It was thought Kyler Murray could be back in the saddle this week, but it was reported on Monday morning that McCoy will once again be under center as Murray continues to deal with a hamstring injury. In what is good news for Arizona, star wideout DeAndre Hopkins is expected to play.
The 5-4 49ers currently own the final wild card spot in the NFC, but the 4-6 Cardinals are not far behind. There’s plenty of football left to be played, and this matchup specifically could have major ramifications in the conference. Below, we will break down this matchup from a gambling perspective and examine the line movement, Over/Under and player props to consider. First, here’s how you can watch Monday night’s matchup.
All NFL odds are via Caesars Sportsbook.
How to watch
Date: Monday, Nov. 21 | Time: 8:15 p.m. ET
Location: Estadio Azteca (Mexico City, Mexico)
TV: ESPN | Stream: fuboTV (try for free)
Follow: CBS Sports App
Odds: 49ers -10, O/U 43
Featured Game | Arizona Cardinals vs. San Francisco 49ers
Line movement
This line reopened at SF -5.5 on Tuesday, Nov. 8, but quickly rose to SF -6 by day’s end. Last Monday, it rose all the way to SF -8. This Monday morning, when it was reported Murray would not be playing, the line flew up to SF -10.
The pick: Cardinals +10. Our panel of eight CBS Sports NFL experts all took the 49ers -8. Throw in Tyler Sullivan and I, and all 10 CBS Sports gambling analysts suggested taking Garoppolo and Co. Now that the line is double digits, however, I find myself leaning the other way. McCoy actually played well against the Rams, completing 26 of 37 passes for 238 yards and one touchdown with a 96.5 rating. I think he’s one of the best backup quarterbacks in…
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