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Cowboys vs. Giants odds, line, spread: 2022 Thanksgiving Day NFL picks, predictions by model on 155-109 roll

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The Dallas Cowboys will try to continue their recent dominance in the all-time series when they host the NFC East-rival New York Giants on NFL Thanksgiving Day 2022. Dallas (7-3) has won three straight and 10 of the last 11 meetings with New York (7-3), including a 23-16 road triumph in Week 3. The Cowboys own a 72-46-2 regular-season record against the Giants and cruised to a 30-3 victory in their only previous Thanksgiving NFL matchup in 1992. Dallas is coming off a 40-3 win at Minnesota, while New York suffered a 31-18 home loss to Detroit last week.

Kickoff from AT&T Stadium is set for 4:30 p.m. ET. Dallas is a 9.5-point favorite in the latest Cowboys vs. Giants odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Giants vs. Cowboys picks, you need to see the NFL predictions and betting advice from SportsLine’s Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and Thanksgiving Day NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Giants vs. Cowboys: 

  • Cowboys vs. Giants spread: Dallas -9.5
  • Cowboys vs. Giants over/under: 45.5 points 
  • Cowboys vs. Giants money line: Dallas -455, New York +345 
  • DAL: Cowboys are 22-8 against the spread in their last 30 games against division-rivals 
  • NYG: Giants are 2-9 ATS in their last 11 meetings with Dallas 
  • Cowboys vs. Giants picks: See picks here

Featured Game | Dallas Cowboys vs. New York Giants

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