NFL Week 12 odds, picks: Cowboys thrash Giants on Thanksgiving, Steelers edge out Colts on Monday night

And just like that, it’s Thanksgiving. We’re nearly two-thirds of the way through the 2022 regular season and we can now treat ourselves to a little bit of turkey and stuffing to celebrate. We also have a great trio of games on Thanksgiving Day to sink our teeth into once the tryptophan kicks in and we submerge into our couches.

Of course, a few of those Thanksgiving games have made their way into my five locks of the week for Week 12 along with a few other games on deck later on this weekend, which include a “Monday Night Football” matchup and a team we’re backing that is laying double digits at home. 

2022 record

Regular season
Locks of the Week ATS: 25-26-4
ATS: 72-86-6
ML: 97-67

All NFL odds via Caesars Sportsbook.

This has the makings of a Cowboys rout, almost in identical fashion to Dallas’ 40-3 win over Minnesota just a few days ago. New York showed some cracks in its foundation in the loss to Detroit and lost several key contributors, including top cornerback Adoree’ Jackson. That should allow the Cowboys offense to continue to hum, but it’s their defense that could really put the game away. The Giants are allowing the second-highest pressure rate (45%) in the NFL this season, while the Cowboys are applying the most pressure to opposing quarterbacks in the league. In Week 3, Dallas pressured Daniel Jones 27 times in the win, which is the third-most of any game this season. With the Giants as banged up as they are and Dallas playing at a championship-caliber level, they’ll win this by double digits. 

Projected score: Cowboys 30, Giants 20
The pick: Cowboys -9.5