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Cowboys vs. Giants odds, line, spread: 2022 Thanksgiving Day NFL picks, predictions by model on 155-109 run

Week 7 NFL picks, odds, 2022 best bets from advanced model: This five-way football parlay pays out 25-1


Second place in the NFC East standings is up for grabs when the Dallas Cowboys host the New York Giants as part of the 2022 NFL Thanksgiving Day schedule. The rivals will enter the Thanksgiving NFL 2022 game with identical 7-3 records, although Dallas posted a 23-16 victory at New York in Week 3. The Cowboys bounced back from a deflating overtime loss at Green Bay with a convincing 40-3 triumph at Minnesota last week, ending the Vikings‘ seven-game winning streak. Meanwhile, the Giants are coming off their second defeat in three contests, a 31-18 home setback against Detroit. Dallas rolled to a 30-3 victory in its only previous Thanksgiving meeting with New York in 1992.

Kickoff from AT&T Stadium is set for 4:30 p.m. ET. Dallas is a 10-point favorite in the latest Cowboys vs. Giants odds from Caesars Sportsbook, while the over/under for total points scored is 45.5. Before making any Giants vs. Cowboys picks, you need to see the NFL predictions and betting advice from SportsLine’s Advanced Computer Model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 12 of the 2022 NFL season on an incredible 155-109 run on top-rated NFL picks that dates back to the 2017 season.

The model also ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Cowboys vs. Giants and just locked in its picks and Thanksgiving Day NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Giants vs. Cowboys: 

  • Cowboys vs. Giants spread: Dallas -10
  • Cowboys vs. Giants over/under: 45.5 points 
  • Cowboys vs. Giants money line: Dallas -455, New York +345 
  • DAL: Cowboys are 22-8 against the spread in their last 30 games against division-rivals 
  • NYG: Giants are 2-9 ATS in their last 11 meetings with Dallas 
  • Cowboys vs. Giants picks: See picks here

Why the Cowboys can cover

After losing his first two career starts against New York, Dak Prescott has been outstanding in the series. The 29-year-old quarterback has led Dallas to victory in his last nine outings versus the division-rival, throwing 20 touchdown passes and only three interceptions…

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