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NFL Thanksgiving odds, how to watch, streaming: Expert selections, best bets, teasers, survivor picks and more

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How about a little football to go alongside your Thanksgiving dinner? The NFL has a triple-header on deck for the Thursday holiday and features a number of playoff hopefuls and Super Bowl threats. In fact, the .650 win percentage between these teams is the second-highest since the league expanded to three games on Thanksgiving. Five of the six teams playing on Thanksgiving also own a winning record, which ties a league-high.  

As we do every week for the entire slate, we’ve collected all of the best Thanksgiving picks and gambling content from and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts as well as additional featured content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. 

All NFL odds via Caesars Sportsbook.

Which picks can you make with confidence in Week 12? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up almost $7,000 for $100 players on top-rated NFL picks since its inception.

Time: Thursday, 12:30 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Bills -10
Current: Bills -9.5

Featured Game | Detroit Lions vs. Buffalo Bills

“This has the makings of a game with a lot of offense. Both teams can score, but the Bills can really score. They will put up a big number here as Josh Allen wins a second straight game in Detroit after beating the Browns last week in the same building. The track is fast and the Bills can fly. The Lions won’t keep up.” — Pete Prisco, CBS Sports Senior NFL analyst, has the Bills covering the 9.5-point spread and has this game going well over the 54.5 total. 

“The Lions have been rolling the past few weeks, but I just have a hard time betting against Josh Allen with this line under double figures. Yes, Detroit’s defense has played better in its previous three games, but that was against the PackersBears and Giants. Buffalo’s offense is a different animal entirely. Allen has historically played…

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