College Football

Clemson vs. South Carolina prediction, odds: College football picks, Palmetto Bowl best bets from proven model

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The South Carolina Gamecocks (7-4) travel to take on the No. 8 Clemson Tigers (10-1) on Saturday afternoon in the 2022 Palmetto Bowl. Bowl teams are bowl eligible and are looking to add another victory to the win column. Clemson has won two straight games, including a 40-10 win over Miami last week. South Carolina comes into this riding high after the Gamecocks upset then-fifth-ranked Tennessee 63-38 in their last outing. Both teams are 6-5 against the spread in 2022. 

Kickoff from Memorial Stadium in Clemson is set for 12 p.m. ET. Caesars Sportsbook lists the Tigers as 14.5-point favorites in the latest South Carolina vs. Clemson odds, while the over/under for total points scored is 52. Before making any South Carolina vs. Clemson picks, be sure to check out the college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on South Carolina vs. Clemson and just revealed its picks and predictions. You can visit SportsLine now to see the model’s picks. Now, here are several college football odds and trends for South Carolina vs. Clemson:

  • South Carolina vs. Clemson spread: Tigers -14.5 
  • South Carolina vs. Clemson Over/Under: 52 points  
  • South Carolina vs. Clemson money line: Tigers -600, Gamecocks -430 
  • CLEM: Tigers are 4-1 ATS in their last 5 games in November 
  • SC: Gamecocks are 5-2-1 ATS in their last 8 non-conference games 
  • South Carolina vs. Clemson picks: See picks here

Featured Game | Clemson Tigers vs. South Carolina Gamecocks

Why Clemson can cover

Junior quarterback DJ Uiagalelei is the lead man for Clemson’s offense. Uiagalelei has a good combination of size, athleticism, and arm strength. The California native owns a strong deep ball and is able to spray the ball…

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