Ohio State vs. Michigan prediction, odds: 2022 Week 13 college football picks, best bets from proven model

The Big Ten East Division title and a spot in the Big Ten Championship Game are on the line on Saturday when the third-ranked Michigan Wolverines battle the second-ranked Ohio State Buckeyes in a rivalry matchup simply referred to as The Game. The Wolverines (11-0, 8-0), who are 3-0 on the road this season, are an impressive 536-216-18 all-time in Big Ten play. The Buckeyes (11-0, 8-0), who are 7-0 at home in 2022, have dominated their opposition, winning all of their games by no fewer than 11 points. This will be the 12th time the teams have met with both ranked in the Associated Press Top 5, the most of any rivalry. Ohio State leads these games in wins 7-3-1.

Kickoff from Ohio Stadium in Columbus, Ohio, is set for noon ET. Michigan leads the all-time series 59-52-2, although Ohio State holds a 28-27-2 edge in games played at Columbus. The Buckeyes are 8-point favorites in the latest Michigan vs. Ohio State odds from Caesars Sportsbook, while the over/under for total points scored is set at 56. Before making any Ohio State vs. Michigan picks, you need to see the college football predictions and betting advice from SportsLine’s proven model.

The SportsLine Projection Model simulates every FBS college football game 10,000 times. Over the past six-plus years, the proprietary computer model has generated a stunning profit of almost $3,000 for $100 players on its top-rated college football picks against the spread. Anyone who has followed it has seen huge returns.

Now, the model has set its sights on Ohio State vs. Michigan and just locked in its picks and CFB predictions. You can head to SportsLine now to see the model’s picks. Now, here are several college football odds and betting lines for Michigan vs. Ohio State:

• Michigan vs. Ohio State spread: Ohio State -8
• Michigan vs. Ohio State over-under: 56 points
• Michigan vs. Ohio State money line: Michigan +250, Ohio State -320
• MICH: The Wolverines are 5-1 against the spread in their last six road games
• OSU: The Buckeyes are 4-0-1 ATS in their last five home games
• Michigan vs. Ohio State picks: See picks at SportsLine