Prisco’s NFL Week 15 picks, plus projected postseason picture and QB Power Rankings

Happy Wednesday, everyone. Joe Burrow and the Bengals are cruising, and John Breech decided to take the day off to rewatch Burrow’s appearance on “Monday Night Football” with the Manning brothers. He can’t get enough! Anyway, you’ve got me, Cody Benjamin, to deliver all the latest from around the NFL.

This is the Pick Six newsletter. Now let’s get to it. (And please, do yourself a favor and make sure you’re signed up to receive this newsletter every day! You don’t want to miss our daily offerings of everything you need to know around the NFL.)

We’ve got Week 15 predictions, quarterback updates, playoff picks and much more:

1. Today’s show: Week 15 betting picks, preview, predictions

Tyler Sullivan joined Will Brinson on Wednesday’s “Pick Six NFL Podcast” to break down all the biggest Week 15 matchups from a betting perspective. Which teams are the safest bets? Which point spreads are suspicious? Here are some highlights:

• Brinson is buying the 49ers (-3) as road favorites on Thursday night, citing the Seahawks‘ porous run defense (which has allowed an NFL-worst 209 yards per game the last four weeks) as a major concern for Seattle. Sully is also leaning San Francisco, but he’s more wary of a potential Brock Purdy slip-up in a “kitchen-sink game” for the home underdogs.
• Both guys are leaning Lions in a pick ’em matchup with the Jets, unsure of Mike White’s status as New York’s battered signal-caller. But Brinson has concerns: “Can Jared Goff go win that game in the cold weather if the Lions can’t run?”
• The Cowboys (-4.5) should be favored against the Jaguars, the guys agreed, even in light of Trevor Lawrence’s recent tear. But they noted Dallas could easily get caught looking ahead to a Week 16 matchup with the NFC East-leading Eagles.

Catch the full episode (and subscribe for daily NFL talk) right here.

2. Prisco’s Picks: Bills rout Dolphins, Commanders edge Giants

Pete Prisco went 9-4 making straight-up picks, and stayed in the green on best bets, for Week 14. Now he’s back with predictions for every single Week 15 matchup. Here’s a sampling:

• Bills 27, Dolphins 17: The Dolphins have lost two straight and they are now playing a third straight road game. That’s brutal. The Bills lost to Miami in the first meeting, even though they…