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49ers at Seahawks odds, picks: Point spread, total, player props, live stream for ‘Thursday Night Football’

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Two NFC West rivals kick off Week 15 of the 2022 NFL regular season, as the Seattle Seahawks host the San Francisco 49ers. The Seahawks lost to the 49ers by 20 points earlier this season, and have lost three of their past four matchups. If the season ended today, Seattle would not be in the postseason. As for the 49ers, things are trending upwards.

San Francisco has won six straight games, and can officially clinch the NFC West with a win Thursday night. Even though Kyle Shanahan is down to his third-string quarterback, it has not slowed the 49ers’ progress. They didn’t miss a beat going from Trey Lance to Jimmy Garoppolo, and now haven’t missed a beat going from Jimmy G to Brock Purdy. This year’s Mr. Irrelevant blew out Tom Brady in his first career start last week, but he’s dealing with a couple of injuries heading into this matchup. 

The 49ers have covered the spread in four straight games while the Seahawks have failed to cover the spread in four straight games. Below, we will break down this matchup from a gambling perspective and examine the line movement, Over/Under and player props to consider. First, here’s how you can watch the game. 

All NFL odds are via Caesars Sportsbook.

How to watch

Date: Thursday, Dec. 15 | Time: 8:15 p.m. ET
Location: Lumen Stadium (Seattle, WA)
Stream: Amazon Prime Video  
Follow: CBS Sports App 
Odds: 49ers -3, O/U 43

Featured Game | Seattle Seahawks vs. San Francisco 49ers

Injury Report

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