The San Francisco 49ers will try to complete a sweep of the season series for the first time since 2011 when they visit the NFC West-rival Seattle Seahawks on Thursday Night Football. San Francisco (9-4) posted a 27-7 home victory against Seattle (7-6) in Week 2 and will clinch its 21st division title with a victory on TNF. The 49ers, who are riding a six-game winning streak, own a 30-17 regular-season record against the Seahawks, but have lost 14 of the last 17 meetings. Seattle has lost three of its last four overall contests to fall two games behind San Francisco.
Kickoff from Lumen Field is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any Seahawks vs. 49ers picks, you need to see the NFL predictions and betting advice from SportsLine’s Advanced Computer Model.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks.
The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, the model has set its sights on 49ers vs. Seahawks and just locked in its picks and Thursday Night Football predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines for Seahawks vs. 49ers:
- 49ers vs. Seahawks spread: San Francisco -3
- 49ers vs. Seahawks over/under: 43 points
- 49ers vs. Seahawks money line: San Francisco -190, Seattle +158
- SF: 49ers are 2-8-1 against the spread in their last 11 games at Seattle
- SEA: Seahawks are 8-2-2 ATS in their last 12 Thursday contests
- 49ers vs. Seahawks picks: See picks here
Featured Game | Seattle Seahawks vs. San Francisco 49ers
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