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Thursday Night Football odds, spread, line: Seahawks vs. 49ers prediction, NFL picks from expert on 19-6 run

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The Seattle Seahawks will try to stay alive in the NFC West title race when they host the rival San Francisco 49ers on Thursday Night Football. After losing three out of their last four games to fall out of the divisional lead, the Seahawks (7-6) need a victory to avoid being eliminated from the divisional title. A win would also help their wild card hopes since they enter Week 15 behind the Commanders and Giants (both 7-5-1) for the final spot in the NFL playoff picture. Meanwhile, the 49ers (9-4) can become the first team in the NFL to clinch a division this season with a victory on TNF.

Kickoff is set for 8:15 p.m. ET. San Francisco is a three-point favorite in the latest Seahawks vs. 49ers odds from Caesars Sportsbook, while the over/under for total points scored is 43. Before making any 49ers vs. Seahawks picks or NFL predictions, you’ll want to see what SportsLine’s resident Seahawks expert, Josh Nagel, has to say.

Nagel is a Nevada-based handicapper with more than 20 years of experience in the sports wagering industry. SportsLine’s assistant managing editor has covered the wagering industry on a variety of platforms and has won numerous sports handicapping contests. He has hit 54% of his NFL picks against the spread (749-636-22) since the start of the 2016 season.

In addition, Nagel has gone 19-6 in his last 25 spread picks involving the Seahawks. Anyone who has followed him is way up.

Now, Nagel has zeroed in on Seahawks vs. 49ers and just locked in his picks and TNF predictions. You can head to SportsLine to see Nagel’s picks. Now, here are several NFL odds and betting lines for Niners. vs. Seahawks:

  • Seahawks vs. 49ers spread: San Francisco -3
  • Seahawks vs. 49ers over/under: 43 points
  • 49ers vs. Seahawks money line: San Francisco -180, Seattle +150
  • SF: 49ers lead the league in scoring defense (15.2 points per game).
  • SEA: LB Jordyn Brooks ranks second in the NFL in tackles (141).
  • Seahawks vs. 49ers picks: See picks at SportsLine

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