Broncos vs. Cardinals prediction, odds, line, spread: 2022 NFL picks, Week 15 best bets from proven model

The Denver Broncos (3-10) are set to host the Arizona Cardinals (4-9) in a matchup between teams in the midst of disappointing seasons on Sunday at Empower Field at Mile High. The Broncos are 2-4 at home, while Arizona is 3-2 on the road. Both teams will be led by their backup quarterbacks with Kyler Murray (knee) out for the year, and Russell Wilson (concussion) out for this game. Brett Rypien will be starting for the Broncos, and Colt McCoy for the Cardinals. Denver is coming off a 34-28 loss to the Kansas City Chiefs and will be looking to snap a five-game losing streak. Arizona is looking to bounce back from its 27-13 loss to the New England Patriots on Monday Night Football.

Kickoff is at 4:05 p.m. ET. Denver is favored by 1.5 points in the latest Broncos vs. Cardinals odds from Caesars Sportsbook, and the over/under is set at 36.5. Before making any Cardinals vs. Broncos picks, you’ll want to see the NFL predictions and betting advice from the proven computer simulation model at SportsLine.

The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 15 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season. The model is also a sizzling 21-5 on straight-up NFL picks over the past two weeks. 

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Broncos vs. Cardinals and just locked in its picks and NFL predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL betting lines for Cardinals vs. Broncos:

• Broncos vs. Cardinals spread: Broncos -1.5
• Broncos vs. Cardinals over/under: 36.5 points
• Broncos vs. Cardinals money line: Denver -125, Arizona +105
• Broncos vs. Cardinals picks: See picks here

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