Several clinching scenarios are at play during the Week 16 NFL schedule, including the NFC’s No. 1 seed. The Eagles can clinch a playoff bye with a win over Dallas, but the Cowboys are 1.5-point favorites in the NFL odds at Caesars Sportsbook with Eagles quarterback Jalen Hurts looking iffy with a shoulder injury. At the opposite end of the standings are the Houston Texans, who are 8.5-point underdogs to the Titans in the latest Week 16 NFL spreads. Houston can clinch the top overall pick in next year’s draft with another defeat plus the Bears pulling off a monumental upset against Buffalo (-9.5). All of the Week 16 NFL lines are listed below, and SportsLine’s advanced computer model has all the NFL betting advice and predictions you need to make the best Week 16 NFL picks now.
The model, which simulates every NFL game 10,000 times, is up more than $7,000 for $100 players on top-rated NFL picks since its inception. The model enters Week 16 of the 2022 NFL season on an incredible 157-113 run on top-rated NFL picks that dates back to the 2017 season.
The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.
Now, it has turned its attention to the latest Week 16 NFL odds and locked in NFL picks for every NFL matchup. Head here to see every pick.
Top Week 16 NFL predictions
One of the model’s strongest Week 16 NFL picks is that the 49ers (-7) cover the spread at home against the Commanders. San Francisco has the longest active winning streak in the league at seven and five of those have come by double-digits. It has covered in six of those contests and is 5-1 against the spread as a home favorite this year.
Washington has failed to cover in back-to-back games, with both of those contests coming against the Giants. Overall, the Commanders have struggled against the league’s upper-echelon teams, covering just once across six games versus teams that win over 55% of their games.
After playing last Thursday, San Francisco will have a rest advantage. The model has the Niners (-7) winning by double-digits and thus covering well over 50% of the time. The model also says the Over (39.5) hits in well over 50% of simulations. See which other teams to pick here.
Top Week 16 NFL survivor picks
The model’s Week 16 NFL…
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