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NFL Week 16 odds, picks, schedule, how to watch, stream: Expert picks, survivor picks, teasers and more

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We are heading down the final stretch of the 2022 regular season and we’re at the point where each week brings with it clinching opportunities. In Week 16, several teams can punch their ticket to the postseason, and two division crowns are there to be clinched as well. As we enjoy the holiday weekend, you won’t want to miss a second of the action. 

As we do every week, we’ve collected all of the best picks and gambling content from CBSSports.com and SportsLine and put them all in one place, so you can get picks against the spread from our CBS Sports experts as well as additional featured content for each game, including plays from top SportsLine experts and the SportsLine Projection Model, best bets from our staff, survivor picks and more. 

All NFL odds via Caesars Sportsbook.

Which picks can you make with confidence in Week 16? And which Super Bowl contender goes down hard? Visit SportsLine, as its incredible model simulates every NFL game 10,000 times and is up more than $7,000 for $100 players on top-rated NFL picks since its inception.

Bills at Bears

Time: Saturday, 1 p.m. ET (CBS), stream on Paramount+ (click here)
Open: Bills -10
Current: Bills -8

Featured Game | Chicago Bears vs. Buffalo Bills

“Weather could be a factor in this game as it’s forecasted to be around 12 degrees during this game with 22 mph winds and gusts up to 38 mph. I think that impacts the Bills offense more than it does the ground-and-pound approach of the Bears, so I’ll gladly take 8.5 points in what could be a lower-scoring affair. Buffalo is 3-3-1 ATS as a road favorite this season and are 2-6 ATS in its last eight games overall, despite sitting as the No. 1 seed in the AFC. With Fields emerging as a dynamic threat with both his arm and legs, he should be able to keep Chicago within range of covering throughout the afternoon or sneaking us in the backdoor late.” — CBS Sports’ Tyler Sullivan on why he is taking the points with Chicago as they host Buffalo. To read the rest of his picks, click here.

Saints at…

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