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Bills vs. Bengals odds, line, spread: Monday Night Football picks, predictions, best bets by proven NFL model

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It’s a massive showdown between two of the AFC’s best teams on Monday Night Football in NFL Week 17 when the Cincinnati Bengals host the Buffalo Bills at Paycor Stadium. Quarterback Josh Allen and the Bills (12-3) hold the top seed for the AFC playoffs, as they are tied with Kansas City but have the head-to-head tiebreaker. Joe Burrow and the Bengals (11-4) also beat the Chiefs but are a game behind Kansas City in the race for the No. 1 seed. The Bills beat the Bears 35-13 last Sunday in Chicago for their sixth straight victory. Cincinnati has won seven in a row and beat the Patriots 22-18 in New England last Sunday. This is the first career matchup between Allen and Burrow, two of the top MVP candidates this season.

Kickoff is set for 8:30 p.m. ET in Cincinnati, Ohio. Buffalo is a 1.5-point favorite in Caesars Sportsbook’s latest Bills vs. Bengals odds, and the over/under for total points scored is 49.5. Before locking in any Bengals vs. Bills picks, be sure to check out the NFL predictions and betting advice from SportsLine’s advanced computer model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model entered Week 17 of the 2022 NFL season on an incredible 158-113 run on top-rated NFL picks that dates back to the 2017 season.

The model ranked in the top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on Bills vs. Bengals and just locked in its picks and MNF predictions. You can head to SportsLine now to see the model’s picks. Here are several NFL odds and betting lines and trends for Bengals vs. Bills:

  • Bills vs. Bengals spread: Buffalo -1.5
  • Bills vs. Bengals over/under: 49.5 points
  • Bills vs. Bengals money line: Buffalo -120, Cincinnati +100
  • BUF: The Bills are 52-42-7 ATS (56%) with coach Sean McDermott (since 2017)
  • CIN: The Bengals are 41-25-2 ATS (62%) with Zac Taylor as coach (since 2019)
  • Bills vs. Bengals picks: See picks at SportsLine

Featured Game | Cincinnati Bengals vs. Buffalo Bills

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