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49ers vs. Seahawks prediction, odds, line, spread: 2023 NFL playoff picks, bets from proven model on 15-6 roll

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The Seattle Seahawks will continue their surprising season when they open NFL Super Wild Card Weekend 2023 against the San Francisco 49ers on Saturday. Seattle (9-8) was expected to endure a second straight losing campaign after trading star quarterback Russell Wilson to Denver last March, but instead earned its fourth playoff berth in five years behind Geno Smith. The 49ers (13-4) were forced to use three starting signal-callers due to injuries, but still captured the NFC West title for the second time in four seasons. San Francisco won both meetings between the division-rivals in 2022 after being swept the previous two years.

Kickoff from Levi’s Stadium is set for 4:30 p.m. ET. San Francisco is a 10-point favorite in the latest 49ers vs. Seahawks odds from Caesars Sportsbook, while the over/under for total points scored is 42.5. Before locking in any Seahawks vs. 49ers picks, make sure you check out the latest NFL predictions and betting advice from SportsLine’s proven projection model.

The model, which simulates every NFL game 10,000 times, is up well over $7,000 for $100 players on top-rated NFL picks since its inception. The model enters the Super Wild Card Weekend in the 2023 NFL playoffs on an incredible 161-113 run on top-rated NFL picks that dates back to the 2017 season. It is also on a 15-6 roll on top-rated NFL picks since Week 7 of this season.

The model ranked in the Top 10 on NFLPickWatch four of the past six years on straight-up NFL picks and beat more than 94% of CBS Sports Football Pick’em players four times during that span. Anyone who has followed it is way up.

Now, the model has set its sights on 49ers vs. Seahawks on Saturday and just locked in its picks and NFL playoff predictions. You can visit SportsLine now to see the picks. Here are the NFL odds and trends for Seahawks vs. 49ers:

  • 49ers vs. Seahawks spread: San Francisco -10 
  • 49ers vs. Seahawks over/under: 42.5 points 
  • 49ers vs. Seahawks money line: San Francisco -475, Seattle +380 
  • SF: 49ers are 8-0 against the spread in their last eight games against division rivals 
  • SEA: Seahawks are 1-7 ATS in their last eight games
  • 49ers vs. Seahawks picks: See picks here

Featured Game | San Francisco 49ers vs. Seattle Seahawks

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