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Seahawks vs. 49ers odds, spread, line, time: 2023 Thanksgiving NFL picks, predictions by expert on 24-10 run

Seahawks vs. 49ers odds, spread, line, time: 2023 Thanksgiving NFL picks, predictions by expert on 24-10 run


The NFL Thanksgiving schedule 2023 concludes with a highly anticipated showdown at Lumen Field. In the first of two meetings between the teams this season, the San Francisco 49ers will take on the Seattle Seahawks in Week 12. San Francisco swept three games against Seattle last season and is 7-3 to begin the 2023 campaign. Seattle is 6-4 overall and 4-1 at home. Both teams’ games went under the total last week.

Kickoff is at 8:20 p.m. ET in Seattle. For this game, SportsLine consensus lists San Francisco as a seven-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest 49ers vs. Seahawks odds. Before making any Seahawks vs. 49ers picks, be sure to see the NFL predictions from Josh Nagel, given his mastery of picks involving Seattle

Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine’s assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. 

Moreover, Nagel has a read on the pulse of the Seahawks. In fact, he is a blistering 24-10 (+1300) on his last 34 NFL picks in games involving Seattle. Anyone who has followed him is way up.

Now, he has locked in on 49ers vs. Seahawks during the 2023 Thanksgiving NFL schedule and released a confident against-the-spread pick. Go to SportsLine to see it. Here are the NFL lines and trends for Seahawks vs. 49ers:

  • 49ers vs. Seahawks spread: 49ers -7
  • 49ers vs. Seahawks over/under: 44 points
  • 49ers vs. Seahawks money line: 49ers -352, Seahawks +274
  • SF: 49ers are 5-5 against the spread this season
  • SEA: Seahawks are 5-4-1 against the spread this season
  • 49ers vs. Seahawks picks: See picks at SportsLine
  • 49ers vs. Seahawks live stream: fubo (try for free)

Why the 49ers can cover

The 49ers boast top-five marks in scoring, yards per play, and total yards this season. Christian McCaffrey leads the NFL with 825 rushing yards and is No. 2 in the league with 1,189 yards from scrimmage. He has seven games with at least 100 total yards this season, and McCaffrey leads the NFL with 14 total touchdowns. He also has dominant numbers against Seattle, including 686 scrimmage yards and six touchdowns in four career matchups.

At wide receiver, Brandon Aiyuk ranks No. 2 with 19.3 yards per reception and averages more than 92 receiving yards per game. Aiyuk…

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