Seahawks vs. 49ers odds, spread, line, time: 2023 Thanksgiving NFL picks, predictions from expert on 24-10 run

Thanksgiving brings a trio of NFL games, with the closest matchup on paper arriving in the evening window. NFC West powers will square off when the Seattle Seahawks host the San Francisco 49ers at Lumen Field. It is the first of two scheduled meetings between the division-rivals this season and Seattle is 4-1 at home in 2023. The Seahawks are also 6-4 overall, and the 49ers enter at 3-2 on the road and 7-3 overall.

Kickoff is at 8:20 p.m. ET in Seattle. For this game, SportsLine consensus lists San Francisco as a seven-point favorite, while the over/under, or total number of points Vegas thinks will be scored, is 44 in the latest 49ers vs. Seahawks odds. Before making any Seahawks vs. 49ers picks, be sure to see the NFL predictions from Josh Nagel, given his mastery of picks involving Seattle. 

Nagel is a Reno-based analyst and radio host who has worked in the sports handicapping industry for more than 20 years. SportsLine’s assistant managing editor has covered the wagering industry on a variety of platforms, and has won numerous sports handicapping contests. 

Moreover, Nagel has a read on the pulse of the Seahawks. In fact, he is a blistering 24-10 (+1300) on his last 34 NFL picks in games involving Seattle. Anyone who has followed him is way up.

Now, he has locked in on 49ers vs. Seahawks during the 2023 Thanksgiving NFL schedule and released a confident against-the-spread pick. Go to SportsLine to see it. Here are the NFL lines and trends for Seahawks vs. 49ers:

• 49ers vs. Seahawks spread: 49ers -7
• 49ers vs. Seahawks over/under: 44 points
• 49ers vs. Seahawks money line: 49ers -352, Seahawks +274
• SF: 49ers are 5-5 against the spread this season
• SEA: Seahawks are 5-4-1 against the spread this season
• 49ers vs. Seahawks picks: See picks at SportsLine
• 49ers vs. Seahawks live stream: fubo (try for free)

Why the 49ers can cover

49ers quarterback Brock Purdy leads the NFL with a 77.1 QBR and 115.1 passer rating this season and posted a perfect passer rating (158.3) against the Tampa Bay Buccaneers in Week 11. Purdy also leads the league in completion rate (70.2%) and yards per pass attempt (9.7) and is only the fourth quarterback ever with at least a 70% completion rate and at least 9.0 yards per attempt through 10 weeks.

Purdy is also in the top eight of the NFL in passing touchdowns (18) and total offense (2,657) and has six touchdowns and no turnovers in two games against Seattle….