Game Predictions | Bills at Eagles

Storyline to watch: The Bills are averaging more yards per game than the Eagles and have a plus-104 point differential compared to plus-61 for Philly. But Buffalo has five more giveaways on the season and has lost all of its games by six points or fewer, while the Eagles have found a way to win the close ones. — Tim McManus

Bold prediction: Josh Allen’s interception streak will come to an end. Despite facing the team with the best record on the road, Allen’s career-high seven-game stretch with at least one interception in each game will come to a close. The offense and Allen’s confidence took a big step in the right direction against the Jets, and that will continue in this big game. Plus, while the Eagles’ defense has plenty to give the Bills a tough day, it has recorded only five interceptions this season, tied for the second fewest in the NFL. — Alaina Getzenberg

Stat to know: Allen has seven games with a passing and rushing TD this season, while Philadelphia’s Jalen Hurts has six. Only four QBs have ever had eight such games in a season, and the record is nine (Kyler Murray in 2020).

Matchup X factor: Bills cornerback Rasul Douglas. He has provided a badly needed boost for the banged-up Bills defense and has allowed just 0.8 yards per coverage snap and recorded two interceptions in his three games with Buffalo. — Walder

What to know for fantasy: The Eagles’ running game holds a significant advantage with D’Andre Swift against a Bills defensive front that ranks 16th in run stop win rate. Swift has averaged 18.0 touches and 14.9 fantasy points per game this season. — Moody

Betting nugget: The Bills’ Allen is 11-5-1 ATS as a road underdog in his career.

Moody’s pick: Eagles 28, Bills 21

Walder’s pick: Bills 28, Eagles 24

FPI prediction: BUF, 55.9% (by an average of 2 points)